Cell motility: Complex dynamics at the leading edge
نویسندگان
چکیده
منابع مشابه
Cell motility: Complex dynamics at the leading edge
The intracellular pathogen Listeria monocytogenes is a useful model for general actin-based cell motility, because it recruits host actin and associated proteins for movement. Recent data have shown that these associated proteins include the Ena/VASP family of proteins and the actin-related proteins Arp2 and Arp3.
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Purse-string healing is driven by contraction of actin/myosin cables that span cells at wound edges, and it is the predominant mode of closing small round wounds in embryonic and some adult epithelia. Wounds can also heal by cell crawling, and my colleagues and I have shown previously that the presence of unconstrained, straight edges in sheets of epithelial cells is a sufficient signal to indu...
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Zonula occludens (ZO)-1 is a multi-domain scaffold protein known to have critical roles in the establishment of cell-cell adhesions and the maintenance of stable tissue structures through the targeting, anchoring, and clustering of transmembrane adhesion molecules and cytoskeletal proteins. Here, we report that ZO-1 directly binds to MRCKβ, a Cdc42 effector kinase that modulates cell protrusion...
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Lin Huo, Wenyu Wen, Rui Wang, Chuen Kam, Jun Xia, Wei Feng* and Mingjie Zhang* Division of Life Science, Molecular Neuroscience Center, State Key Laboratory of Molecular Neuroscience, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, Department of Chemistry, Shanghai, China, Institutes of Biomedical Sciences, Fudan University, Shanghai, China and National Labo...
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ژورنال
عنوان ژورنال: Current Biology
سال: 1997
ISSN: 0960-9822
DOI: 10.1016/s0960-9822(97)70079-4